You, Me and the Big C is a British podcast about life with, treatment of and other topics relating to the disease cancer.

The podcast was originally hosted by three former or current cancer patients; Deborah James, Lauren Mahon and Rachael Bland.

James died from cancer in June 2022, leaving Mahon as the only surviving original host.

Each episode is hosted by different people and covers various aspects of cancer.

Former presenter Rachael Bland stated in an interview with The Guardian newspaper: "We wanted to create a space where you feel like you're sitting down with girls like you, having a cup of tea, talking about it like it's EastEnders.