The game was released in North America on February 8, 2011, for Microsoft Windows, Nintendo DS, PlayStation 3, Wii and Xbox 360 platforms.

A single player iOS port was released about two months later, but was later pulled in anticipation of a more robust client based on the Facebook version of the game.

You Don't Know Jack was generally well-received, seen as a humorous return to form for the series, though the lack of online play or additional content for the Windows version was criticized.

Each game uses a pre-defined set of ten questions from over seventy episodes, titled by the name of the show's fictional sponsor.

[1] For example, one question asks the players to identify which Jennifer Aniston film title would most likely have been suited for a hypothetical romantic comedy penned by Albert Einstein about the interactions between neutrons and electrons, the answer being "He's Just Not That Into You".

One particular question type has players choose from the same four answer choices, namely Kangaroo, Peanut, Albert Einstein and Uranus.

For example, one DisOrDat series asks the players to identify terms that would be features of a Nexus One phone, Nexxus shampoo, or both.

Prior to the round, a brief clue is shown to the players to describe a relationship that they must match, for example "BFF" (Best Friends Forever).

[3] Jellyvision Games sought comedy writers, including from local comedy clubs such as Second City and I.O., narrowing down the pool of applicants from hundreds to six, including Second City comedian Tim Sniffen, who had worked on previous iterations of the You Don't Know Jack series.

[7][8] A weekly training process was employed to bring the new writers up to speed and review previously written dialog for possible improvements.

[5] Tom Gottlieb was also involved in the writing process, as Jellyvision Games credits much of the "Cookie" persona to his own performance of the character.

The company does not rule out future iterations of the game being released to a wider market based on the success of this title.

[12][13][14] You Don't Know Jack was positively received by critics who were delighted not only with a new entry in the series, but one that kept the same humor and wit as the earlier games.

Seth Schiesel of The New York Times praised the "triumphant, hilarious and even enlightening return" of the series, citing the creativity of the writing and voice work.

[2] Chris Watters of GameSpot commented that the structure of each episode can become repetitive, and that commonly the Jack Attack round would decide the winner of the game, negating the previous questions, but still considered the "large amount of legitimately clever and surprisingly funny writing" a key aspect of making You Don't Know Jack as "one of the most entertaining trivia games on the market".

[19] GamePro's Nathan Grayson was more critical of the game's lack of features, considering the number of questions "painfully short" compared to the Buzz!

[17] The Windows version was particularly criticized as it did not allow for online play, a feature available on the Xbox 360 and PlayStation 3 releases, nor would receive the downloadable content for the game.