"You Know What" is a song by American singer Avant featuring rapper Lil Wayne.

It was written by Avant, Lil Wayne, Jermaine Dupri, and Manuel Seal for his fourth studio album Director (2006), while production was helmed by Dupri and Seal.

Geffen Records released the song as the lead single from the album.

An accompanying music video for "You Know What" was directed by Benny Boom and filmed in Los Angeles, California.

The video shows Avant finding a girl, portrayed by Candace Pillay, and gets attracted to her.