The track was written by lead singer Jason Wade and American record producer Jude Cole.

A music video for the song premiered on MTV.com on March 21, 2005, and features a couple as Wade sings in a train station.

"You and Me" has appeared on many television shows, including Smallville, Grey's Anatomy, The Vampire Diaries, Cold Case and Gavin & Stacey.

The song was written by Lifehouse lead singer Jason Wade and American record producer Jude Cole.

[2] In an interview with MTV, Wade explained his experience working with Alagía, and said, "When we walked into John's house, we didn't know what to expect, and we get in there and the mixing board is in the living room, the B3 [organ] is in the kitchen and the piano is over there.

And he's so nonchalant about all his stuff — there'd be a triple-platinum Dave Matthews Band plaque sticking out from under the bed.

"[8] Ultimate Guitar called the song "a tender love-ballad" and noted how it would be "a perfect soundtrack for a wedding.

"[9] Alternative Addiction said that the song was embraced by fans in the same way "Hanging by a Moment" was when Lifehouse started as a band.

[11] It is composed in the key of G major with Wade's vocal range spanning from the low-note of B2 to the high-note of E4.

[25] The video starts with a woman exiting the taxi and going to the Los Angeles Union Station.

When the chorus plays again, they are shown at the roof with lights from the buildings of Downtown Los Angeles at night.

The man and the woman are also seen running in the boarding area of the Los Angeles Union Station.

On April 20, 2005, Lifehouse made a guest appearance in the Smallville season 4 episode "Spirit" and performed "You and Me" among other songs on stage.