Originally released as a single in November 1994, it became the group's biggest hit.

[2] Appearing on the band's third album, Be a Girl, the song was also included on their next album, Bagsy Me, due to the success of the re-released single and the song's appearance on the soundtrack of Baz Luhrmann's film Romeo + Juliet.

For the second UK single release, the song's title acquired an ampersand.

The B-side, "Blister in the Sun", is a cover of a song by the Violent Femmes.

In a 2003 episode of the long-running British soap opera Coronation Street, "You & Me Song" was playing when Richard Hillman drove his wife Gail Platt, two of her children David and Sarah and granddaughter Bethany into the canal, which resulted in Richard's death.