He has created artwork for a variety of well known entertainers including Foster the People, The Velvet Teen, Maroon 5, Robin Thicke, Mikky Ekko, T. Mills, Andy Dick, Jerry Stiller, L.A. Salami and others.

[2][9][10] In 2014, Zane Lowe and BBC Radio 1 called Young & Sick the "Next Hype" and the project was named Stereogum's "Band to Watch.

[5][19] Jimmy Fallon "loved" the artwork, even creating an improv song about the art entitled "kill the boogers" with Adam Levine after learning that the drawing first featured mucus coming from the nose.

[10] American singer-songwriter Mikky Ekko, rapper T. Mills, and producer Skrillex also feature artwork completed by Young & Sick.

[23] In June 2015, van Hofwegen was commissioned to reimagine the classic Pringles can for an artistic campaign the brand did alongside Fergie of the Black Eyed Peas.

[24] Later in 2015, The Fader and Coors Light retained van Hofwegen to create artwork for a three event concert series in LA featuring Kali Uchis, HEALTH, and Shlohmo.

[3][32] In February 2013, Young & Sick was commissioned by fashion retailer Rag & Bone to paint a mural on their store in SoHo, New York City.

[3] In January 2015, MeUndies, an online retailer of specializing in fashion underwear, released a new pattern entitled "faces" designed by Young & Sick.

[33] In 2018, in conjunction with the release of his Ojai EP, Van Hofwegen designed a set of sneakers with Threadless featuring his artwork from the album.

[37] In March 2013 Young & Sick turned down six-figure recording contracts from major music labels to release their second single "Continuum" via Tor "The Underweb".

[44] In 2015, Young & Sick teamed up with JD Samson (Le Tigre) to create a side project called SHARER.

[47] A limited edition 7" three-color splatter vinyl of Ojai was released by B3Sci, featuring original artwork from Van Hofwegen on the cover, album sleeve, and folded poster.

[55] The follow-up single "Jet Black Heart" was featured on KCRW's Best New Music list, where Marion Hodges said it was "beautifully constructed as a driving piece of synth pop.

[58] In 2014, van Hofwegen co-wrote the song "Caught In The Middle" for Charli XCX's album "Sucker" alongside Benny Blanco.