Kesha notably performed the song alongside "Tik Tok" on the 35th season of Saturday Night Live where she was covered in glow-in-the-dark tribal-like make-up.

The video also features a digital animation sequence which was inspired by the Beatles' 1968 film Yellow Submarine.

"Your Love Is My Drug" was written by Kesha, alongside her mother Pebe Sebert and Joshua Coleman.

"[2] "Your Love Is My Drug" is a mid-tempo[3] dance-pop song combining Auto-Tune–processed vocals layered with a heavy electronic backdrop.

Sara Anderson of AOL Radio called the song a "bubblegum track fused with '80s glam rock", with "Kesha's signature auto-tuned vocals and casual chatty ad-libs".

[3] Fraser McAlpine from BBC complimented the song and Kesha for knowing her way around a strong pop chorus, giving the single four out of five stars.

McAlpine noted that "some evidence of range would be welcomed at this point,[...] [since] there's a whole other side to her that you'd never know if you just listened to the singles" commenting that her persona was the "boozy floozy card" and that the power ballads on her album could have been better for a release.

[7] Sara Anderson of AOL Radio called the song "a playful take on a teen love obsession", complimenting "Kesha's signature auto-tuned vocals and casual chatty ad-libs".

[5] Nate Adams of No Ripcord was positive in his review of the song, calling it "a fun little disco tune", and wrote that the singer "isn't reinventing the wheel by any stretch of the imagination, but she has her share of catchy would-be hits.

"[8] Robert Copsey of Digital Spy gave the song four out of five stars, commenting that although she sings through the verses in her "usual speak-sing fashion", the chorus is "joyously irresistible".

[14] "Your Love Is My Drug" also peaked at number one on Billboard's Hot Dance Club Songs where it stayed for one week.

[16] In 2024, the song had been certified 5× platinum by the Recording Industry Association of America (RIAA) for sales of 5,000,000 equivalent units.

[24] Kesha described the concept behind the video in an interview with MTV, stating, "I wanted it to be like a psychedelic trip of the mind, comparable with being so disgustingly in love with someone that you lose your head.

Kesha walks through the desert while split scenes of her are shown where she is riding an elephant and wearing a tiger mask while crawling around in the sand.

The video then cuts to another scene where Kesha is covered in glow in the dark body paint while dancing around in a cave with a python around her neck.

[30] James Montgomery from MTV said that "Your Love Is My Drug" was a "supremely catchy pop tune" and that the video was "the perfectly blissed-out accompaniment."

Montgomery chided the video for "not making much sense" but noted "that hardly matters" as "Kesha has stumbled on a perfect formula for pop success: Don't think too big, or too much.

"[29] This song was performed on a season 35 episode Saturday Night Live hosted by Ryan Phillippe on April 17, 2010.

[31] On May 29, 2010, Kesha performed "Your Love Is My Drug" alongside previous single "Tik Tok" at the MTV Video Music Awards Japan.