The podcast was started in 2010 and covers a wide range of topics such as ongoing events, comedy, and the daily life of the two co-hosts—interspersed with toilet humor, running jokes, and commentary on unusual or shocking internet videos.

This includes creating "YMH Celebrities"[1] by repeatedly playing videos of nicknamed, socially-untypical members of the public, in "a modern variation of the regular callers into The Howard Stern Show.

In 2012, Your Mom's House was chosen as a finalist in the Best Comedy category at the first annual Stitcher Awards, along with Smodcast, The Adam Carolla Show, The Joe Rogan Experience, The Nerdist, and WTF with Marc Maron.

[7] In January 2023, Segura and Pazsitzky announced a new show on YMH Studios' network hosted by Rob Iler and Jamie-Lynn Sigler of The Sopranos and the Pajama Pants podcast.

As of 2022 the studio has produced three live shows for 2 Bears 1 Cave (including a Big Game event with NFL Hall of Famer Warren Sapp), and nine for Your Mom's House.

Episodes often feature prominent guests from the world of entertainment and pop culture, notably fellow stand-up comedians such as Bert Kreischer, Joe Rogan, Andrew Santino, Tom Papa, Josh Wolf, Chad Daniels, Matteo Lane, Stavros Halkias, Robert Kelly, Louis CK, Bobby Lee, Andrew Schulz, Ari Shaffir and Adam Friedland.

[11] Guest hosts include YMH team members Christina P and Dr. Drew, comedians Ryan Sickler, Tim Dillon, Whitney Cummings, Bobby Lee, and LeeAnn Kreischer.