She has provided the music for several popular anime series, such as Sword Art Online, Puella Magi Madoka Magica, Fate/Zero, The Garden of Sinners, Pandora Hearts and Demon Slayer: Kimetsu no Yaiba.

In 2004, the duo produced the opening and ending songs for Kōichi Mashimo's Madlax and in the next year, published their first collaborative album, Destination.

In October 2007, it was announced that Yuki Kajiura would be attending the performances of the Eminence Orchestra's concert, 'A Night in Fantasia 2007 – Symphonic Anime Edition', as a special guest.

[4] In July 2016, Aniplex of America announced that the “Yuki Kajiura LIVE ~featuring SWORD ART ONLINE~” concert that took place in March 2016 in Japan would be having an additional date on January 14, 2017, at the Dolby Theatre in Los Angeles, California, but was later canceled due to visa issues.

[5] In December 2017, a source reported to a news site, Sponchi Annex that Kajiura was planning to leave her agency, Spacecraft Produce, over contract disputes.