[1][2] Kishida was born in Miyoshi City, Hiroshima Prefecture, as the eldest daughter of Kunijirō Wada, a real estate company owner.

[3] After graduating from high school, she attended Tokyo Women's Christian University to study Japanese literature.

She joined Mazda to work as secretary of vice president Yoshihiro Wada in 1987 after graduating from TWCU.

[4] On 17 April 2023, Yuko Kishida traveled solo to the United States at the invitation of the First Lady, Jill Biden, making her the first spouse of a Japanese Prime Minister to have made a solo visit to the United States.

[5][6][7] During her visit, Kishida and Jill Biden planted a cherry blossom tree within the White House grounds as a symbol of the enduring friendship between the United States and Japan.