Mizutani was best known for her anime voice roles of Sakiko Sakura in Chibi Maruko-chan, Mihoshi Kuramitsu in Tenchi Muyo!

She also portrayed Excellen Browning in Super Robot Wars, Sora Takenouchi in Digimon Adventure, Leina Stol in Machine Robo: Revenge of Cronos, and Sarah Zabiarov and Cheimin Noa in Mobile Suit Zeta Gundam.

[2] Since her death, Aya Endō took over as the Japanese voice of Minnie Mouse and Machiko Toyoshima took over as Sakiko Sakura in Chibi Maruko-chan.

After playing the role of Sarah Zabiarov in Mobile Suit Zeta Gundam, her portrayals of Leina Stol in Machine Robo: Revenge of Cronos and Apple in Zillion were highly praised and her popularity grew.

In addition to animation and video games at the Tokyo Disney Resort, she also appeared as Minnie Mouse in attractions, shows, and parades.