Yusuf Grillo (16 December 1934 – 23 August 2021) was a Nigerian contemporary painter, muralist and sculptor, known for his inventive works and the prominence of the color blue in many of his paintings.

He later studied various specialist courses at Cambridge University and later traveled to Germany and the United States of America.

He started to teach at Yaba Technical Institute in 1962 under Paul Mount, the then Head of Department.

Grillo is considered to have been one of Nigeria's outstanding academically trained painters; he emerged to prominence and international recognition in the 1960s and 1970s, while exhibiting a large collection of his early works.

His preference for color blue in natural settings paintings, is sometimes similar to the adire or resist-dye textiles used in Nigeria.