Yūzō Saeki (佐伯 祐三, Saeki Yūzō, 28 April 1898 – 16 August 1928) was a Japanese painter, noted for his work in developing modernism and Fauvist Expressionism within the yōga (Western-style) art movement in early twentieth-century Japanese painting.

He attended the Académie de la Grande Chaumière in Paris, where fellow Japanese painter Katsuzo Satomi introduced him to the Fauvist painter, anarchist and journalist Maurice de Vlaminck, who was strongly critical of his work, and whose comments influenced his later technique.

Saeki favored portraiture and landscape paintings of Parisian city scenes, especially the backstreets, bars and buildings in the style of Maurice Utrillo or Vincent van Gogh.

However, Saeki could not find inspiration in the suburbs of Tokyo, and in August 1927, traveling via the Trans-Siberian Railway, he returned to France.

His frenetic efforts at depicting the streets of Paris led to a deterioration in the tuberculosis he had long suffered from.