After moving to South Egremont, she befriended Impressionist painters Charles and Katherine Almond Hulbert, and received her first painting instruction from them.
[9][10] In 1925, Humber moved to New York City to study at the National Academy of Design, and beginning in 1928, took concurrent classes at the Art Students League, where she began to develop a Regionalist painting style.
[2] As a student in New York, Humber exhibited works at Jean Roosevelt's GRD Studio, the Three Arts Club, and Macy's department store.
[8] In 1933 and 1934, Humber received fellowships from the Tiffany Foundation to paint in Oyster Bay, New York, where she was influenced by artists such as Luigi Lucioni, Edna Reindel, and Paul Cadmus.
[8][1] Humber's work shifted after moving to the Northwest, and she heavily favored depicting natural landscapes over the city scenes she had previously been known for.
[8][12] She earned a local reputation for standing out from the Northwest School of artists, which included Mark Tobey, Morris Graves, and Guy Anderson.
[11] In 1946, she had a solo exhibition at the Seattle Art Museum, and won a prize for her painting Green River, which was shown with the National League of American Pen Women at the Smithsonian Institution.
[8][13] Though she continued to work with oils and hard-edge styles, she began to abandon Regionalism and experimented with printmaking, Sumi painting, and serigraphs in the 1970s.