Several transcription factors with scores greater than 0.9 are predicted to regulate ZNF821 expression.

The protein encoded by the ZNF821 gene is 412 amino acids long with a calculated molecular weight of ~ 47 kDa and a predicted isoelectric point of 6.14.

[9][10][11][12] The tertiary structure of the ZNF821 protein provides exposure of the Zinc Fingers for presumed DNA-binding.

The relative rate of divergence is slow when compared to the rates of two reference proteins, Cytochrome c and Fibrinogen alpha, but increases to slightly faster than Cytochrome c as the date of divergence gets closer to the present.

It has been implicated in causing craniosynostosis through interactions with the transcription factor BCL11B by affecting the charges on the arginine-3, arginine-5, and lysine-3 residues, thereby increasing their conformational flexibility.

[18] It has also been found to be a possible biomarker for methamphetamine-associated psychosis (MAP) via the process of RNA-degradation.

[19] Another disease association is that with breast cancer as part of a DNA-repair sub network.

[20] Finally, there is a study showing an increase in methylation over time on ZNF821 in Parkinson's disease patients who did not receive L-dopa/entacapone.