100507290319748ENSG00000261221ENSMUSG00000074405P0CJ78Q3U3I9NM_001195605NM_001033383NM_001290426NP_001182534NP_001028555NP_001277355ZNF865[5] (also referred to as BLST [2-4][6]) is a C2H2 member of the zinc finger family of proteins.

Lack of expression of ZNF865 has been associated with increased incidence of Parkinson’s disease,[8] worse outcome measures in esophageal cancer,[8] and increased incidence of musculoskeletal diseases.

[7][9] Bioinformatics analysis predicts ZNF865 to be localized to the nucleus, and function in metal ion binding, DNA-binding transcription factor activity, interact with RNA polymerase II, and regulate transcription by RNA polymerase II.

[9] Experimental data displays ZNF865 is a regulator of cellular senescence, cell cycle progression, DNA replication, DNA repair, and protein processing.

Overall, ZNF865 has been confirmed as a regulator of cellular senescence, cell cycle progression, and DNA replication.