After several constructions, additions of chapels and renovations and occasional fires that occurred over 170 years, a definitive project was reached in 1732 that sought to integrate some walls and sculptures of the previous temples to build.

It possesses three facades, the northern one is dedicated to the Santo Cristo de la Parroquia, considered by the ancient miners as being extremely miraculous; the southern one honours Our Lady of the Zacatecas, patron saint of the city; while the principal one was finished on April, 24 of 1745, this one takes inspiration of the Sacred Communion; in it can be found the representations of the Holy Father, the Son and the Holy Spirit being accompanied by the Apostles, all around the Eucharist, carved in the key of the rosette window.

On January 26, 1863, Pope Pius IX issued the bull that erected the Diocese of Zacatecas, raising the rank of the temple to a cathedral.

The third temple, already with three naves, had its baroque wooden altarpieces, which were replaced by quarry ones, possibly designed by the Valencian architect Manuel Tolsá between 1803 and 1847, except for the largest one.

The original dome was replaced by the current, which bears a strong resemblance to the Templo de Loreto in Mexico City.

It consists of two parts, the first arc of half point, its spandrels have vegetable ornaments and angels, has a copy in stone of a Christ who is inside.

The second body, more elaborate than the first, a set framed by columns stipes with the image of Christ, the Virgin Mary and St. Joseph, with a curtain deployed by angels.

It was constructed from geometric prisms born of the upper platform of the sanctuary and contains niches where elaborate images of saints are placed.

The third temple, already with three naves, had its Baroque wooden altarpieces, which were replaced by quarry ones, possibly designed by the Valencian architect Manuel Tolsá between 1803 and 1847, except for the largest one, which is said to have been dismantled in 1852. thus causing an architectural and liturgical vacuum.

Subsequently, a first cypress was built in this same year, which remained until 1895, which was later replaced by a second smaller one, thus giving rise to the concern to cover the front wall with an allegorical painting of the Assumption of the Virgin, a work carried out by Master Manuel Pastrana.

Finally, the construction of a new altarpiece for the main altar, designed by the Michoacán artist Javier Marín, was started and was completed in 2010.

It was built from geometric prisms born from the high platform of the presbytery, which create spaces in the form of niches where the elaborate images of the saints sit.

On the sides were placed the images of the Zacatecas martyrs San Mateo Correa and Blessed Miguel Agustín Pro.