Zacharie Astruc (23 February 1833 in Angers – 24 May 1907 in Paris) was a French sculptor, painter, poet, and art critic.

Astruc was an important figure in the cultural life of France in the second half of the 19th century, and participated in the First Impressionist Exhibition of 1874 and also in the Exposition Universelle of 1900.

As an art critic, writing primarily between 1859–72, he was a strong defender of Courbet, and was one of the first to recognize the talent of Manet, who he had befriended as early as 1854, or 1857 at the latest.

"[4][5] Astruc helped to promote a widespread revival of interest in El Greco's paintings.

[10] Along with many figures in the French art world of the late 1800s, Astruc inspired a character in French writer Marius Roux's novel The Substance and the Shadow, a roman à clef whose main character was a thinly disguised Paul Cézanne.