[5] He also has the distinct record of dismissing Graeme Smith, Kumar Sangakkara, Sanath Jayasuriya and Matthew Hayden – some of the game's most feared left-handed batsmen – over 10 times each in international cricket, and also holds the record for dismissing the third-most number of left-handed batsmen (237), after Muttiah Muralitharan (325), and Shaun Pollock (252).

During the course of his career, Khan sustained recurring injuries, which often interrupted his progress at the international level, and this was the reason he set up ProSport Fitness & Services, a special rehabilitation & training center in association with Adrian Le Roux and Andrew Leipus.

He also played in the local Revenue Colony Cricket Club (RCC) in Shrirampur after which he started his career in Pune.

His ability with the bat was recalled by another former teammate with who Khan put together a 102-run stand for ninth wicket making an unbeaten 62 runs taking his team home.

In 2005 Khan, signed for Worcestershire County Cricket Club in England as one of their two overseas players, replacing Shoaib Akhtar.

[17] In June he took the first nine wickets to fall in the first innings against Essex, ending with 9–138; had wicket-keeper Steven Davies not dropped a catch offered by last man Darren Gough he would have become the first bowler ever to take all ten for the county.

[2] In late 2005 pacemen Sreesanth and R. P. Singh made their international debuts and became regular members of the Indian team making it difficult for Zaheer to retain his position in the playing eleven.

The Board of Control for Cricket in India demoted Zaheer from a B-grade to a C-grade contract at the end of the year.

Late in 2006, Zaheer was recalled to the Test and ODI team for the tour of South Africa, following Irfan Pathan's slump in form and an injury to Munaf Patel.

[19] He is also the fourth highest wicket-taker in ODIs for India with 282 scalps behind Anil Kumble (337), Javagal Srinath (315) and Ajit Agarkar (288).

In an interview he said : "The whole 2011 World Cup, I was looking forward to it, especially playing in front of the home crowd – even if it added that extra bit of pressure.

Zaheer has 44 World Cup wickets, spanning from 2003 to 2011, putting him in ninth place behind Glenn McGrath (71), Muttiah Muralitharan (68), Mitchell Starc(65), Lasith Malinga (56), Wasim Akram (55), Trent Boult(53) and Chaminda Vaas (49) on the list of highest number of wickets by a bowler in the marquee event.

Zaheer, who was one of India's trump cards during their World Cup triumph in 2011, finished as the joint highest wicket-taker along with Shahid Afridi with 21 scalps.

Having bowled 13.3 overs, Zaheer strained his hamstring and suffered an ankle injury in the first Test of the four-match series and as a result was ruled out of the rest of the tour.

[28] Involving personnel such as Andrew Leipus and Adrian Le Roux, the center aims to "maximize potential" of people and athletes by personally assisted fitness programs.

Khan stated that the objective was to "bring in world class fitness program to India for sports injury management".

[29][30][31] It offers scientifically designed programs and treatment while conducting workshops and sessions for corporates and schools to spread awareness of physical fitness.