[1] Born in Constantinople, Ottoman Empire, Zakarian received his primary education at a local school.
After finishing Collège Sainte-Barbe's medical institution, he worked in hospitals.
Zakarian participated in international exhibitions, was awarded gold medals in 1889 and 1900 and Chevalier de la Légion d'honneur in 1899.
[3] Edgar Degas, who was Zakarian's friend, painted his portrait in 1886.
There are works by Zakarian in the museums of Paris, Yerevan, Echmiatsin, Venice and Beirut.