Zakare along with his father Sargis supported the rebellion of Prince Demna and the Orbelian family in 1177, however they soon sided with George III and fought for the monarchy against the insurgents.

[5] Following the death of George III, Queen Tamar elevated Sargis Zakarian (Mkhargrdzeli)— a well-born valorous man, well-trained in battle — to the office of Amirspasalar (Lord High Constable) and granted him possessions over Lori (which was deprived of from Kubasar).

[6] In the ninth year of Tamar's reign, the Mandaturtukhutsesi and Amirspasalar Zakaria (Zakare) Mkhargrdzeli and his brother Ivane the atabeg took Dvin in 1193.

[7][8] Zakare commanded the Georgian army for almost three decades, achieving major victories at Shamkor in 1195 and Basian[9] in 1203 and leading raids into northern Iran[10] who played a significant role.

...If you dare to take my brother out of the city, or do something to him, I will Conquer the land of your country and give it to Georgian Kingdom and I'm gonna kill all of you...The Ayyubids demanded a Thirty Years' Truce in exchange for Ivan's release.