[8] From the late 1960s, he acted as the personal interpreter and adviser to the founder of the UAE, Sheikh Zayed bin Sultan Al Nahyan.

[17][18] In 1975, Zaki Nusseibeh became the Director of the Press Office in the Diwan (Court) of Sheikh Zayed,[11] subsequently becoming an Adviser while continuing his role as the President's personal interpreter.

[5][10] Zaki Nusseibeh has served on several public and private bodies dealing with the development of cultural and educational strategies in the UAE.

[26] He is also a member on several other Boards including the Sheikh Zayed Book Award (2005–present),[27] the International Prize for ArabicFiction (2009–present)[21] and Abu Dhabi University (2003–present).

[29] Nusseibeh was the chairman of the advisory board for the Middle East Centre of the London School of Economics (2015-2018),[30] as well as the President of the Alliance Française in Paris (2013-2017).

[3][19] He was also the President of the Alliance Française Abu Dhabi (1977-2017)[31] and of the UAE Chapter of the International Friends of Richard Wagner Society (2008–present)[32] and a member of the Board of Trustees of the Agha Khan Museum in Toronto (2016-2019).

[33] His Excellency has been conferred many national orders of merit in recognition of his distinguished service; His Excellency has received notable awards for his work for the arts and cultural diplomacy: Zaki Nusseibeh's daughter is Lana Nusseibeh, a diplomat who serves as the United Arab Emirates Permanent Representative to the United Nations since September 2013.