Zamboanga del Sur's 2nd congressional district is one of the two congressional districts of the Philippines in the province of Zamboanga del Sur.

It has been represented in the House of Representatives since 1987.

[3] The district encompasses the southern half of the province consisting of the municipalities of Bayog, Dimataling, Dinas, Dumalinao, Guipos, Kumalarang, Lakewood, Lapuyan, Margosatubig, Pitogo, San Miguel, San Pablo, Tabina, Tigbao and Vincenzo A.

Sagun.

[4] It is currently represented in the 19th Congress by Jeyzel Victoria Yu of the Lakas–CMD.