Zamorano is host to students from several countries, including Honduras, Guatemala, El Salvador, Nicaragua, Costa Rica, Panama, Ecuador, Peru, Colombia, Chile, Bolivia, Haiti, Dominican Republic, Paraguay, and Mexico.

[citation needed] The school was founded in 1941 by Samuel Zemurray (1877–1961) a Russian born American and president of the United Fruit Company.

To carry out this dream, he recruited Dr. Wilson Popenoe, a renowned botanist and horticulturist of the time who had extensive experience in the region, and had already organised the Lancetilla Botanical Gardens in Honduras.

The entire property lies on approximately 70 km², including natural forests and two micro basins, large productive areas, many places for recreation and various buildings.

There are green areas, paths and lagoons harbouring numerous wild species that have found natural shelter on the Zamorano campus.

It has over 18,000 specialised books, 6,500 technical brochures, access to online databases worldwide, digital documents and a considerable number of magazines.

Each business unit is managed by means of an agribusiness plan and agro-budget so that operations are handled as a company with financial and educational goals.

[citation needed] Some of these alumni include: Jose Antonio Molina (Botanist, Honduras '46), Marcel Laniado (Banker, Ecuador '49), Carlos Eduardo Mesa Mesa (Business Magnate, Colombia), Eduardo Galo (Novus International Director of North America, Honduras '95), Jose Rene Portillo, Cojutepeque, El Salvador.