The series follows the friendships and relationship of five female friends who enjoy the steamy stories of erotic writer Zane.

[1] The series follows heroine Patience James and her girlfriends, Eboni, Maricruz, Lyric, and Ana Marie as they take on their lives in the big city, look for love and empower themselves—both in and out of the bedroom.

Zane posted an update on September 13, 2010 on Facebook about the future of the show: "Many of you have asked about the return of Zane's Sex Chronicles on Cinemax for a third season and I realize that a lot of you ordered the channel just for me.

For those of you who got really caught up in the characters, there is a tie-in book for the series that digs deeper into their backgrounds and relationships.

It is entitled Zane's Sex Chronicles, exactly like the show."