He previously played for the South Sydney Rabbitohs, Wests Tigers and St George Illawarra Dragons in the NRL.

Born in Auckland, New Zealand, Musgrove is of Samoan and Māori descent and played his junior rugby league for Counties Manukau and the Mangere East Hawks.

[8][9] In the 2018 season, injuries and suspension prevented Musgrove from making a single appearance for Souths, playing twice for their feeder club, the North Sydney Bears, instead.

[11][12] In December, Musgrove was charged with indecent assault for an alleged incident at the Coogee Bay Hotel that occurred two days after he signed with the Wests Tigers.

A statement from the NRL read "A request by the Wests Tigers to register Zane Musgrove, who is currently facing indecent assault charges, has been refused until the case is concluded".

[16] On 31 January, Musgrove and fellow NRL player Asu Kepaoa were detained by the police after allegedly abusing officers and refusing to move on from outside of the Coogee Bay Hotel.

[19] Musgrove played a total of 24 matches for the Wests Tigers in the 2022 NRL season as the club finished bottom of the table and claimed the Wooden Spoon for the first time.

[21] On 21 February, Musgrove was issued with a breach notice and fined by St. George Illawarra after he was involved in an altercation with teammate Mikaele Ravalawa following the clubs Charity Shield loss to South Sydney in Mudgee.

[25] Musgrove played 25 games for Warrington in the 2024 Super League season as the club reached the semi-final before losing to Hull Kingston Rovers.