She is known for her unwanted and controversial divorce from her first husband Karl-Muzak Thopia, as commanded by Skanderbeg, Lord of Albania.

After Skanderbeg returned to Krujë, he looked for alliances with local Albanian princes.

As such, he offered, or possibly forced, a marriage annulment between the couple in order to have his sister Mamiza Kastrioti marry Zanfina's husband.

Later on, she married prince Moisi Golemi from the Arianiti family, who would eventually become one of Skanderbeg's commanders.

Both Karl-Muzakë Thopia and Moisi Arianiti were captured by the Ottomans, with the latter being taken to Costantinople where he was executed.