Viz Media licensed the anime for the English dub, which aired on Cartoon Network's Toonami in the United States and on YTV's Bionix in Canada starting April 1, 2006.

[11] The opening theme in the English airing of the season is “Follow the Light,” excluding the first two episodes (51 and 52) in which "Zatch Bell!

Zatch and Kiyo witness Zofis’ machinations firsthand and attempt to hinder him, but he and Koko flee with their army.

Riddles and Kido soon pinpoint Zofis to an ancient ruin in South America and send Kiyo and Zatch there to confront him.

Zatch and his allies reunite by the Stone of Moonlight, the source of Zofis’ powers, which is guarded by the thousand-year Mamodo Demolt whose sheer size and strength prove formidable for the protagonists.

However, several of Zofis’ minions; Penny, Byonko, and the thousand-year Mamodo Laila; defect to Zatch and help him vanquish Demolt and destroy the stone.

Content at the outcome, Sherry and Brago send Zofis back to the Mamodo world, while Zatch, Kiyo, their friends, and the liberated humans head home, yet Riddles senses that an even greater danger is imminent.