Zeltiq Aesthetics is a subsidiary of AbbVie based in Pleasanton, California that markets and licenses devices used for cryolipolysis procedures.

[4] Zeltiq was founded in 2005 as Juniper Medical, Inc., by Mitch Levinson, who had previously led Thermage, a company that sold devices for radio frequency skin tightening.

[7] The company developed a medical device to remove fat using a process called cryolipolysis, which it branded as "CoolSculpting".

[8] The device works by pulling a piece of flesh between two paddles, which cool it to below freezing and hold the temperature there for a half hour or so.

[19] The device received FDA clearance to be marketed for removing love handle fat from people's sides in September 2010[20] and from the stomach in 2012.

[25] In 2014, Zeltiq introduced a new model of the CoolSculpting device obviating the suction cup and was cleared by the FDA for use on thighs.

[32] Other studies, however, indicate that side effects are common on a per-patient basis, since a typical patient receives multiple treatments.