[9] The convention typically offers anime and live action screenings, AMV's, artist alley, concerts, cosplay masquerade, costume competitions, dances, dealers room, formal costume ball, game shows, iron cosplay, karaoke, LARP, live bands, maid cafe, manga library, panels, swap meet, tabletop gaming, vendors, video gaming, and workshops.

During the convention in 2011, Zenkaikon and its attendees raised $3750 for the American Red Cross Japanese Earthquake and Pacific Tsunami Relief Fund.

[11][24] Due to construction of the Valley Forge Casino Resort at the Valley Forge Convention Center, Zenkaikon 2012 was held at a new location, The Greater Philadelphia Expo Center at Oaks, and reduced to two days.

[1][25][26] Zenkaikon moved to the Lancaster County Convention Center for 2013 and returned to being a three-day event.

[14] The convention expanded to the Holiday Inn Lancaster in 2024 and moved the gaming programming there.

[53] Zentrancon was an anime and science fiction convention held on October 16, 2005 at The Rotunda, University of Pennsylvania.

Zenkaikon returned to VGXPO 2009 on October 9–11, 2009 and provided two screening rooms for anime.

[61] Zenkaikon hosted a Cosplay Fashion Show in Fairmount Park during Sakura Sunday at the 2012 Subaru Cherry Blossom Festival of Greater Philadelphia.