Zenodotion (Ancient Greek: Ζηνοδότιον), or Zenodotium or Zenodotia, was a city in Mesopotamia that was destroyed in the 1st century BCE.
Zenodotion was a polis of Osroene near Nicephorium (modern Raqqa, in Syria), though we do not know its exact location.
It is possible that the city was founded by a man in the army of Alexander the Great or Antigonus I Monophthalmus, or a member of the Seleucid Empire, but there is no compelling evidence to show the way here.
[1] Plutarch tells the story of the invasion of Marcus Licinius Crassus into the region, and how Zenodotion, ruled by Apollonius, was the only city that offered significant resistance.
He later hailed himself as Imperator for this feat, which attracted the scorn of his contemporaries, as this was not considered that impressive a victory at all.