Growing up in Greek family culture, Frudakis began drawing and reading at a young age, initiating a lifelong discipline of studying and creating art each day.

Frudakis' first important commission was a portrait sculpture of Samuel L. Evans, founder of the American Foundation for Negro Affairs (AFNA); followed by portrait sculptures of Wilson Goode, former mayor of Philadelphia, Pennsylvania; The Honorable K. Leroy Irvis, the first African American to serve as a State Legislature's Speaker of the House; and Joseph E. Coleman, former City Council President, Philadelphia, Pennsylvania.

The sculpture was installed just inside the embassy's fence, visible to the public but outside the South African government's reach, standing as a statement of the U.S.’s opposition to apartheid.

[7] Frudakis' statue of attorney Clarence Darrow reawakened tensions between local evolutionists and creationists when it was installed outside the Rhea County Courthouse in Dayton, Tennessee, in 2017.

[10] Frudakis has been commissioned to create bronze portrait busts, statues, and monuments of significant figures from the sports world, including golf, baseball, hockey and boxing.

Thousands of television and online viewers saw these images; Payne's daughter Chelsea was photographed with her father's sculpture and the PGA Tour called it on Instagram, "The coolest statue photo you’ll see this week."

Frudakis’ larger-than-life sculptures include Baseball Hall of Famers Mike Schmidt, Steve Carlton, Richie Ashburn and Robin Roberts, all on view at Citizens Bank Park, Philadelphia.

The sculpture was unveiled on September 27, 2018, attended by a large crowd including local and county officials, Braddock's family, fans and other notable boxers Gerry Cooney, Pat Murphy, Randy Neumann, and the legendary "Bayonne Bleeder," Chuck Wepner.

Frudakis has sculpted a wide range of subject matter in bronze, stainless steel and clay, including monuments, memorial, portrait busts, statues, military, sports, animals, people and historic figures.

His best-known and most acclaimed works include Freedom, the United States Air Force Memorial Honor Guard, Payne Stewart, John D. McArthur, Clarence Darrow, Frederick Law Olmsted, James Braddock and Nina Simone.

The 8-foot bronze statue honoring Palm Beach Gardens’ city founder John D. MacArthur is mounted on a 3-foot base of granite from a quarry in Vermont.

[17] Commissioned by The North Carolina Arboretum, the first larger-than-life-size sculpture of Frederick Law Olmsted is a tribute to the man known as the father of American landscape architecture.

"[18][19][20] The memorial sculpture of Nina Simone depicts the "High Priestess of Soul" seated atop a stone base while performing on a floating keyboard.

Using Francis Bacon's quote, "Knowledge is Power" as the central theme, Frudakis sculpted this monument to inspire the process and pleasure of learning.

Relief faces and quotes from 31 iconic figures in science, history, mathematics and the arts portray contrasting theories, philosophies and politics, as well as struggles shared across generations.

On the left page, a large relief portrait of Charles Darwin is encircled by early thinkers, artists, activists, politicians and scientists along with their famous ideas or works.

[1] The design of the sculpture was initially more sketch-like but as it progressed became more detailed with precise measurements for positioning of clothing, ties, medals, buttons, shoes, straps, belts, accessories, flags and rifles, following the strict guidelines of the Honor Guard.

Installed in downtown Philadelphia, at 20 ft. long by 8 ft. high and 7,000 lbs., the monument portrays transformation through the sequential emergence of a figure in four stages of breaking free from a wall.

In a career spanning over four decades, Frudakis has produced monumental figures such as the United States Air Force Memorial Honor Guard[35] Installed at the Arlington National Cemetery, and Freedom in Philadelphia, Pennsylvania[36]