Established December 29, 2003 in Providence, Rhode Island and later headquartered in Boston, Massachusetts, it developed a smart alarm clock with sleep monitor (e.g., REM).

The founders and board members include Daniel Rothman, Ben Rubin, Eric Shashoua, Jason Donahue, Terri Alpert from Stony Creek Brands, David Barone from Sleep Labs, Inc. and Jeff Stibel from Web.com.

[10][11] The proprietary headband, which was recommend to be replaced about every three months, is no longer available from Zeo, Inc. At least some of the assets were acquired by ResMed in Ireland,[12] widely known for their CPAP machines.

Users had reported before the company closed that disposable adhesive gel ECG electrodes with offset press-stud connections worked successfully, better than the Zeo headband.

[15] During the company's existence ZeoScope software using the decoder library, which allowed the Zeo to be used as a biofeedback device with EEG display and functionality related to lucid dreaming, had been written by an independent developer and distributed without charge under the Apache licence; it did not use facilities of the Zeo Web site, and continued to work after the company closed.