[citation needed] A new building was constructed at 10th Avenue and 10th Street at the cost of fifty thousand dollars and was dedicated on September 10, 1926.

Early rivals for the Zephyrs included their current archrival, Pasco High School from nearby Dade City.

One of the students on that first team was Richard Kelly, who would serve as a Member of the US House of Representatives for Florida's 5th congressional district from 1975 until he failed his bid for renomination in the midst of the Abscam scandal in 1981.

[5] In 1964, Zephyrhills High School won its first Florida state championship in basketball.

In response to this and the phenomenal growth of the Zephyrhills area, a new high school was built in the "Hercules Tract" on 12th Street at the cost of three million dollars.

[5] In 2012, the Principal of Zephyrhills High School, Steve Van Gorden, resigned amid allegations of sexual harassment.