[2][3] Her father, Kebede Woldegiorgis, was an architect, and her mother, Engida Mitiku, was a housewife who was thirty years younger than her husband.

As a young girl in a quiet house in Gulele, Zeritu Kebede read books voraciously, listened to country stories suggested by the house help, played and watched football with her brother, and spent time on trees watching birds and the neighbourhood beyond the fences in pursuit of entertainment.

At Express Band, Kebede played songs of Celine Dion, Tracey Chapman, Mariah Carey, Lauryn Hill, Shania Twain, Norah Jones and Shakira, among others, at several events and clubs.

Zeritu then auditioned successfully for a role in a television drama series to be directed by the renowned Ethiopian director, Abate Mekuria.

Although the drama she auditioned for never aired, she performed in another play written and directed by Abate Mekuria and took part in the East African Theater Festival held in Mombasa, Kenya.

While working on her own debut album at Begena Studio, Kebede was offered a part on a group song that was being produced for raising awareness on HIV/AIDS.

The song "Mela", written by Mikael Belayneh and Yilma Gebreab and produced by Elias Melka (whom she met through their mutual friend and her guitar coach, Zekarias Getahun), involved singers like Menelik Wossenachew, Alemayehu Eshete, and Tamrat Mola.

From March 2006 to April 2006, Kebede went on a national tour Guzo Zeritu and performed in major Ethiopian cities including Addis Ababa, Adama, Hawassa, Dire Dawa, Harar, Bahir Dar, Jimma, Mekelle, Dessie and Gondar.

Jean Albert Levier, the director of the environmental documentary Les syndrome du titanic has used Kebede's song "Yane" as the sound track for his film, which is based on the best selling book of the well-known French ecologist Nicolas Hulot.

[8] The music video features various musicians cameo appearance like Jano Band's members Dibekulu Tafesse and Hailu Amelga, Betty G, Henok Mehari, Lij Michael and Dan Admasu.

Zeritu collaborated with singer Tadele Gemechu and released "Lib Yaleh" on 24 October 2019 through Minew Shewa Entertainment.

The music video, funded by a Global Affairs Canada grant through the University of Alberta's Maternal Health project in Ethiopia, was directed by Daniel Tamrat, and produced by UNICEF Ambassador Thomas T. Gobena.

[9][10] Zeritu has been featured artist of Sofia Shibabaw's single "Yeselam Sew Neñ", released on 24 April 2020, along with ensemble musicians like Chachi Tadesse, Betty G and Israel Abel.

In the film, Kebede plays a slightly tom-boyish college girl who refuses to date stating it is a waste of time since we all really are alone.