[4] Hughes won the bronze medal in the same event at the 2024 Summer Olympics, along with Mitchell-Blake and Kilty, in addition to debutants Jeremiah Azu and Louie Hinchliffe.

[5] Hughes trains with the Racers Track Club in Jamaica under coach Glen Mills, with clubmates including Usain Bolt, Yohan Blake and Delano Williams.

He was selected to represent Anguilla at the 2012 World Junior Championships in Athletics (his global debut) and was a semi-finalist in the short sprints, as well as setting a national record of 20.90 seconds.

He ended that year with a personal best of 10.42 seconds for the 100 m.[9] He was awarded a scholarship in 2012 to attend the IAAF's Regional High Performance Training Centre in Jamaica and began to study at Kingston College.

[11] Hughes continued to progress in the 2013 season, winning 100 m gold at both the 2013 CARIFTA Games and the 2013 Pan American Junior Athletics Championships.

He also made his first appearance in senior international competition at the 2013 Central American and Caribbean Championships in Athletics, reaching the final and recording a personal best of 10.23 seconds in the heats.

[8] As a resident of a British Overseas Territories, Hughes was eligible to compete for Team GB and, following in the footsteps of fellow Anguillian Shara Proctor, he ultimately confirmed in June 2015 that he would represent Great Britain in all World Athletics events.

[15] Former British sprinters Darren Campbell and Daniel Caines supported Hughes, noting that Britain was the home nation for people from its colonies.

[17] Hughes made his Diamond League debut in June at the adidas Grand Prix in New York, where he was commended for almost beating world champion Usain Bolt.

[22] Hughes missed the 2016 Olympic Games in Rio due to a tear in his right knee ligament, sustained in a fall earlier in the season.

[25][26] With his teammates Hughes won in the 4 × 100 metres relay, where he ran the second leg alongside Reuben Arthur, Richard Kilty and Harry Aikines-Aryeetey for England.

[31][32] Hughes and the British team placed second in the 4x100 relay, but were disqualified when teammate CJ Ujah was found guilty of doping.

[39][40][41][42][43] In July 2023, at the British Athletics Championships, Hughes ran 19.77, faster than John Regis's national 200 metre record, but with a slightly too strong following wind (2.4 m/s) for record purposes, although his winning margin of 0.66 seconds was the largest winning margin for the men's 200 metres at these championships for over thirty years.

[57] In December 2024, it was announced that Hughes had signed up for the inaugural season of the Michael Johnson founded Grand Slam Track.