The contest earned him both a guest spot on Hunan TV's Happy Camp variety show and a spokesperson role for Wenquxing, an electronic dictionary maker.

Zhou Mi continued to participate in multiple singing competitions in 2005, even after moving from Beijing to Zhuhai, in southern Guangdong Province, for his studies.

[5] In 2006, Zhou Mi joined CCTV's Challenging the Host, a televised national competition for aspiring MCs from all over China.

As a representative of Guangzhou, Zhou Mi and 79 other contestants attended an offscreen training camp, learning about broadcasting from professionals and CCTV mentors.

Before the final 16 could compete, Zhou Mi received an offer from SM Entertainment and decided to put his studies on hold in order to go to Korea in late 2006.

he performed a song from Toy (토이) with the titled 내가 너의 곁에 잠시 살았다는걸 (That I was once by your side), and then he signed a contract with SM Entertainment and began his trainee career.

[20] In February 2011, Zhou Mi played a supporting role in the Chinese drama Melody of Youth, which became his debut in that industry.

[29] In 2012, Zhou Mi was cast as the main role in the idol drama When Love Walked In alongside label-mate Victoria Song, and Calvin Chen of the group Fahrenheit.

[30][31] The drama premiered on August 27 on Anhui, Hubei, Shaanxi and Sichuan Satellite TV, and reached the number one spot in viewership ratings.

Later in 2013, Zhou Mi was chosen to be a radio DJ on MBC's C-Radio Idol True Colour with Miss A members Jia and Fei.

[49] The program on the new media platform showcases content produced by the network and targets the large number of 'hallyu' or 'Korean wave' fans in China.

In this album, Zhou Mi contributed lyrics to their lead single, "Swing", and another song entitled "Fly High".

[54] In 2014, Zhou Mi was chosen to host the Korean-Chinese Variety Show titled Strongest Group with his labelmate Victoria Song.

[55] Zhou Mi then wrote the Chinese version of the track "Run" for another SM group, EXO's, second EP Overdose.

[citation needed] On October 22, 2014, Zhou Mi became an MC for season 4 of the SBS MTV's music program The Show with Park Ji-yeon (T-ara) and Hongbin (VIXX).

[60] In 2015, Zhou Mi was cast in the drama Best Couple He played as Yan Xi Cheng, who comes from a poor background and through hard work becomes a top star.

This drama is set in the modern day Korean entertainment industry and is the first TV production project from China's e-commerce company Alibaba.

[62][63][64][65] Zhou Mi also participated in Super Junior special album, Devil, was released to celebrate the group's 10th anniversary.

He wrote lyrics for "Forever with You", which was sung by Super Junior-M.[66][67] In early 2016, it was confirmed that Zhou Mi would continue to host the 5th season of SBS MTV The Show with new co-MC, GFriend's Yerin.

[74] On May 6, 2019, Zhou Mi held a fan meeting in Tokyo, Japan, and the Japanese version of "The Lonely Flame" was released on the same day.

[75] Zhou Mi participated in the music event dedicated to the 70th anniversary of China and sang "Sing a Folk Song for the Party".

[76][77][78] On June 22, 2020, Zhou Mi collaborated with fellow Super Junior-M member Ryeowook for a song entitled "Starry Night".

[83] On June 1, 2023, Zhou Mi collaborated with fellow Super Junior-M member Eunhyuk to release a new single "Mañana (Our Drama)".

[89][90] On June 29, 2024, Zhou Mi collaborated with Zhang Liyin released a new single, "Don't Go Today", through Easy Entertainment, as a remake of the original by Ben and Im Se-jun.

[91][92] On August 5, 2024, Super Junior-D&E collaborated with Siwon, Zhou Mi, Ryeowook, and Kyuhyun to release a new single entitled "Promise".

[99] On October 19, 2024, Zhou Mi was invited by Half Smile Foundation to promote the art shirts derived from the paintings of autistic children.