Zhou She (周捨) (469–524), courtesy name Shengyi (昇逸), formally Viscount Jian (簡子, literally "the undiscriminating viscount"), was an official of the Chinese Liang Dynasty.
He was never titular prime minister, and never held an office of high rank, but was largely considered a de facto prime minister and was well regarded by his contemporaries.
His father Zhou Yong (周顒) was a Southern Qi official.
When Zhou She was young, he became known for his skills in rhetoric, and he was retained by Wang Liang (王亮), then the mayor of the capital Jiankang, to serve as his secretary.
In 503, Fan died, and Emperor Wu entrusted the important matters of state to Zhou She and Xu Mian, effectively making them co-prime ministers, even though neither carried the title and neither received particularly high rank.