Zikir Muhammadjonov was born on 1 January (according to other sources – 14 August[2]) 1921 in Tashkent.
Since 1938 he was an actor of the State Uzbek Drama Theater [ru] named after Hamza.
He played over three hundred roles, including Ulugh Beg, Abu-Reyhan Biruni, Ali-Shir Nava'i, Husayn Bayqarah, Amir Temur.
The war prevented him from starting his studies, during which (1941–1943) he worked at an aircraft factory, in Tashkent, where he mastered plumbing.
Muhammadjonov graduated from the Tashkent State Institute of Theater Arts named after I.