Eventually she saved up enough money to enter Byfield Academy and study under the charismatic clergyman Joseph Emerson, a leading proponent of women's education.

From 1824 to 1827 (or 1828), Grant served as principal of Adams Female Academy at Derry, New Hampshire.

Grant's curricula at Adams and Ipswich reflected Emerson's influence; they blended rigorous academic studies, moral oversight, and teacher training.

Grant expected students to study for the joy of learning, rather than working for grades or prizes.

Mary Lyon was Grant's assistant and, later, principal at Ipswich until she left to found Mount Holyoke Seminary in 1834.