Zilupe (Latgalian: Sīnuoja, from sīna – 'border'; German: Rosenau, Russian: Розеново) is a town in Ludza Municipality, in the Latgale region of Latvia, by the Zilupe River, on the border with Russia.

After becoming part of the Republic of Latvia the settlement was renamed after the river Zilupe.

After World War II several large enterprises opened their divisions in Zilupe.

These included a metal fabricating workshop, small textile factory and bakery.

The town is near the A12 road, that after the border crossing into Russia turns into the M9, both of which are part of European route E22.