Zipi y Zape are the names of two Spanish comic book characters created by José Escobar in 1947, and of their eponymous strip.

Other featured characters are their father, Don Pantuflo Zapatilla, a professor of Philately and Colombophilia (pantuflo/a and zapatilla are both Spanish names for slippers); their hard-pressed mother, Doña Jaimita; Don Minervo, their strict teacher; Peloto, the teacher's pet (and thus the twins’ enemy); Sapientín (sometimes called "Pitagorin", as a reference to Pithagoras), their genius cousin and Pepe and Felisa Plómez, the extremely annoying friends of their parents, whose undesirable visits they try to avoid or shorten.

They are humorous, based on the twins' antics and their effects, since often they backfire spectacularly, including popular culture elements like aliens and mad scientists.

The series continues after Escobar's death, now in the hands of cartoonists Juan Carlos Ramis and Joaquín Cera who have put them forward to the 21st century.

Zipi and Zape are still domestic terrorists, but now are fans of the UEFA Champions League and make good use of the Internet.