The organization emerged following a forum on transgender healthcare at Camp Betty, a festival of radical sex and politics that was held 7–11 June 2007 in Melbourne.
"[2] Following the forum, a group of activists from the local SGD community began a campaign to establish a 'gender centre' for Victoria.
In a 24 October 2010 media release, the organization criticised the Brumby Government's GLBTI-related election promises as "(forgetting) the 'T' and 'I'".
[7] On 24 November, the Victorian Labor Party issued its own letter of support for Zoe Belle Gender Collective, written by then-Deputy Premier and Attorney-General Rob Hulls.
In December 2011, Zoe Belle Gender Collective was one of seven recipients of a $4 million package from the Baillieu Government to address suicide and self-harm among LGBTI young people.