In her solo performances and recordings Keating uses live electronic sampling and repetition in order to layer the sound of her cello, creating rhythmically dense musical structures.

Keating's songs have been featured in various commercials, TV shows, films, video games, and dance performances including HBO's White Lotus, Amazon Prime's Mammals, CBS's Elementary, NBC's Crisis, So You Think You Can Dance, MTV's Teen Wolf, Dateline, Have You Heard from Johannesburg, The Day Carl Sandburg Died, Alice Walker: Beauty in Truth, The Retrieval, The Witness, and PBS's Searching: Our Quest for Meaning in the Age of Science.

In 2021, during the height of the coronavirus pandemic, Keating co-composed, along with longtime collaborator Jeff Russo, the score to the HBO movie Oslo, a film adaptation of the Tony Award-winning play.

On July 13, 2021, Keating and Russo's score for Oslo was nominated for a 2021 Emmy for Outstanding Music Composition For A Limited Or Anthology Series, Movie Or Special.

[11] After local media publicized the story, Anthem Blue Cross reversed its decision, telling Keating in a phone call that the hospital stay would be covered.

In October 2016 she was invited to participate in a panel discussion at the Frontiers Conference with President Barack Obama, Riccardo Sabatini and Kafui Dzirasa, moderated by Atul Guwande.