Zushi is located at the head of Miura Peninsula, facing Sagami Bay on the Pacific Ocean.

The city is built on an alluvial plain formed by the Tagoe River (田越川) and surrounded by low, steep hills.

During the Edo period, along with most of eastern Sagami Province, the area was tenryō territory under direct control of the Tokugawa shogunate, and administered by various hatamoto.

In the April 1, 1889, cadastral reform after the Meiji Restoration, Tagoe Village within Miura District Kanagawa Prefecture was created through the merger of six local hamlets.

[6] To prevent the building of 800 additional U.S. military housing units a citizen's group called the Association to Stop the US Residential Construction and to Protect Ikego Forest launched an opposition movement in 2004.

Zushi is twinned with:[citation needed] Kanagawa Prefectural Board of Education operates area public high schools.