Located on Lake Union, the address of the ZymoGenetics headquarters was 1201 Eastlake Avenue East.

[9][10] ZymoGenetics' headquarters was previously in the landmark Lake Union Steam Plant building.

[11] This structure was built from 1914 to 1921 by Seattle City Light, the municipal electric utility.

[13] In December 2016, ZymoGenetics announced that they would not renew the lease to the Steam Plant building, due to expire in 2019;[14] the Fred Hutchinson Cancer Research Center later moved into it.

[15] At the time, ZymoGenetics did not plan on closing its Bothell manufacturing site;[14] however, it was sold to Seattle Genetics in August 2017.