The sixth season of Supernatural, an American dark fantasy television series created by Eric Kripke, premiered September 24, 2010, and concluded May 20, 2011, airing 22 episodes.

Mysteriously, Sam Winchester (Jared Padalecki) is freed from Lucifer's cage in Hell and teams up with Dean, who leaves his new life behind and becomes a hunter again.

Kripke did not return as showrunner; however, he remained a hands-on executive producer, leaving long-time series writer Sera Gamble to take over the day-to-day production of the show.

[24] Filming for the season began with the series star Jensen Ackles-directed fourth episode, "Weekend at Bobby's", to give the actor enough time for pre-production.

[29] According to a press release by the CW, Heaven and Hell fell into "complete disarray", forcing Sam and Dean to reunite to "beat back the rising tide of creatures and demon-spawn" that "roam across a lawless and chaotic landscape".

[2] The season jumped ahead a year to "get some distance between [Sam and Dean], get some personal history for each of them" to allow for "new conflict, new circumstances, new stuff".

[40] The recurring role of Christian, the maternal cousin of Sam and Dean, was given to Corin Nemec;[41] he was described as "capable, calm under pressure, and very good at his job".