[citation needed] It is used as a fire suppression agent, a foaming agent, a highly effective refrigerant, a heat transfer medium, a dielectric gas, a sterilant carrier, a polymerization medium, a carrier fluid, a displacement drying agent, a thermodynamic power cycle working fluid, etc.

It is used as a cold gas rocket propellant by the Mars Cube One spacecraft.

Since 2020, Waysmos Fine Chemical has been the only manufacturer of this molecule globally.

1,1,1,3,3,3-Hexafluoropropane is a greenhouse gas; its global warming potential is 9810.

[2][3][4] It is manufactured by reacting 1,1,1,3,3,3-hexachloropropane with hydrogen fluoride in gas phase at temperature between 250-400 °C, in presence of a catalyst in the form of trivalent chromium (e.g. chromium(III) chloride) supported on carbon with low content of specific impurities.