[4][5] Insertion of an N-H moiety into a hydrazide by a copper carbenoid, followed by treatment with ammonium chloride also gives the triazine core.

[6] Amine-substituted triazines called Guanamines are prepared by the condensation of cyanoguanidine with the corresponding nitrile:[7] As a reagent in organic synthesis, s-triazine is used as the equivalent of hydrogen cyanide (HCN).

One application is in the Gattermann reaction, used to attach the formyl group to aromatic substrates.

Cyanuric chloride (2,4,6-trichloro-1,3,5-triazine) is the starting point for the manufacture of many herbicides such as Simazine and atrazine.

Chlorinated triazines are the basis of an important family of reactive dyes, which are covalently attached to cellulosic materials.