106th Infantry Regiment is a reserve unit of the Philippine Commonwealth Army activated in January 1942 to augment the forces in Mindanao.

[1] In late January 1st Battalion, 102nd Infantry was brought by Major Alvin T. Wilson for a refresher training.

However, General Sharp Mindanao Force Commander ordered Colonel Dalton and the Provisional Battalion, 43rd US Infantry under Major Allen Peck to transfer to Bukidnon to set up a training school with the Philippine Scouts as instructor, leaving only 1/102nd Infantry, 2 PC Companies, and trainees in the sector.

The soldiers of this battalion mostly came from the city, and their main mission was to secure Wolfe Field for use as bomber base.

[1] On February 26, the 1942 Japanese 3rd Southern Expeditionary Fleet under Vice Admiral Fugiyama Rokuzo appeared in the coast of Zamboanga.